André Tremblay, PhD
Professor titulaire, CHU Ste-Justine, University of Montreal
- 514 345-4931 ext. 2830
- Centre de Recherche CHU Ste-Justine
3175, Côte Sainte-Catherine
Montréal, Qc, H3T 1C5
Nuclear receptors are transcription factors that control gene expression in response to hormonal stimulation. In the laboratory, we study in particular the ERα and ERβ estrogen receptors that are responsible for the hormonal response of reproductive tissues, the RAR receptors that respond to vitamin A derivatives, and those in the PPAR family (α, β, and γ) which are essential regulators of energy metabolism.
Our studies allow to characterize the hormonal response with that of growth factors and cytokines on the regulation of target genes under the control of nuclear receptors. These studies will allow a better understanding of the role of cellular effectors in gynecological pathology and to identify new therapeutic targets.