Alexandre Boyer, PhD
Associate Professor, Faculty of Veterinary Medicine, University of Montreal
Intérêts de recherche
My laboratory is interested in the mechanisms of action and the roles played by various signaling pathways in the development, maintenance of tissue homeostasis and function of endocrine tissues such as the testis and the adrenal cortex. In recent years our attention has focused on the role of the Hippo signaling pathway; an evolutionarily conserved signaling pathway playing an important role in cell proliferation and differentiation. Using functional genomics approaches (cell cultures and transgenic mouse models), we have recently demonstrated that this signaling pathway plays an essential role in the development of the gonads and adrenal glands. Currently, we are continuing our studies on this signaling pathway in order to understand its mechanism of action in mature Sertoli cells and thus better understand how the latter maintain a structural, nutritional and immunoprotective environment necessary for the maturation of germ cells.